First-Line vs. Second-Line Quit Smoking Treatments: What’s the Difference? Quit Hero

First-Line vs. Second-Line Quit Smoking Treatments: What’s the Difference?

When it comes to quitting smoking, knowing your options makes all the difference. You’ve probably heard of nicotine patches or even vaping but did you know there are two official categories of quit-smoking aids in Australia? Let’s break down the difference between first-line and second-line treatments, what they mean for your quit journey, and how to choose the option that’s right for you.

What Are First-Line Treatments?

First-line treatments are the go-to tools health professionals recommend when someone wants to quit smoking. These have been carefully reviewed and approved by the Therapeutic Goods Administration (TGA) — Australia’s regulatory body for therapeutic products.

In simple terms, these are products that have passed safety, quality, and effectiveness checks, and are registered on the Australian Register of Therapeutic Goods (ARTG). You can find them at most pharmacies and, in some cases, even in supermarkets.

Common First-Line Quit Aids

Nicotine Replacement Therapy (NRT)
Includes patches, gum, lozenges, inhalers, and nasal sprays. These help ease cravings and withdrawal by providing small, controlled doses of nicotine without the harmful chemicals in cigarettes.
Available over the counter

Prescription Medications
Medications like varenicline or bupropion work on the brain’s nicotine receptors to reduce the urge to smoke. These require a script and are usually recommended when NRT alone hasn’t worked.
Must be prescribed by a doctor

What Are Second-Line Treatments?

Second-line treatments are not officially approved by the TGA but can still be used under specific conditions. These are typically considered when first-line methods haven’t worked — especially for people who’ve already tried to quit multiple times.

Vaping nicotine is one of the most talked-about second-line treatments in Australia.

Nicotine Vaping Products

  • As of October 2021, nicotine vapes are classed as a second-line quitting option
  • They can only be accessed with a valid prescription
  • Products must meet minimum quality standards (under TGO 110)
  • Supply must happen under medical supervision

So, while nicotine vapes aren’t officially "approved medicines," they are allowed when other treatments haven’t worked — but only under regulated, prescription-only access.

Important: Nicotine vapes are not risk-free and aren’t intended for casual or recreational use. They’re for adult smokers who have struggled with quitting using other methods.

Why Does This Matter?

Understanding the difference between first- and second-line treatments helps you:

  • Make more informed decisions about your quit journey
  • Understand the legal and medical requirements around vaping
  • Work more effectively with a GP or pharmacist to find the right treatment path for you

Quitting isn’t one-size-fits-all. What works for one person might not work for another — and that’s okay. The key is choosing a safe, evidence-based approach that meets your needs.

How to Get Started

Talk to Your Doctor or Pharmacist
They can help you weigh up your options and guide you toward the treatment that best fits your history and goals.

Start with First-Line Treatments
If you haven’t already, try nicotine replacement therapies or talk to your doctor about prescription medications.

Consider Second-Line Options if Needed
If first-line options haven’t worked for you, your doctor may consider prescribing a nicotine vape that meets Australian safety standards.

Navigating Quitting with Support

You don’t have to navigate quitting alone. Whether it’s your first or fifth attempt, there are safe, regulated options available to help you quit — and stay quit. First-line treatments are still the preferred starting point, but if you’ve tried and struggled, second-line options like vaping under medical guidance might offer another path forward. 

At Quit Hero, we’re here to help you explore these options with confidence and support every step of the way.